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Faculty of Arts and HumanitiesDean's Office, Faculty of Arts and HumanitiesJakobi 2, r 116-121 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of History and ArchaeologyJakobi 2 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Estonian and General LinguisticsJakobi 2, IV korrus 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Philosophy and SemioticsJakobi 2, III korrus, ruumid 302-337 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Cultural ResearchÜlikooli 16 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of Foreign Languages and CulturesLossi 3 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Theology and Religious StudiesÜlikooli 18 50090 Tartu linn, Tartu linn, Tartumaa EST0Viljandi Culture AcademyPosti 1 71004 Viljandi linn, Viljandimaa EST0Professors emeritus, Faculty of Arts and Humanities0Associate Professors emeritus, Faculty of Arts and Humanities0Faculty of Social SciencesDean's Office, Faculty of Social SciencesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of EducationJakobi 5 51005 Tartu linn, Tartu linn, Tartumaa EST0Johan Skytte Institute of Political StudiesLossi 36, ruum 301 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Economics and Business AdministrationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of PsychologyNäituse 2 50409 Tartu linn, Tartu linn, Tartumaa EST0School of LawNäituse 20 - 324 50409 Tartu linn, Tartu linn, Tartumaa EST0Institute of Social StudiesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Narva CollegeRaekoja plats 2 20307 Narva linn, Ida-Virumaa EST0Pärnu CollegeRingi 35 80012 Pärnu linn, Pärnu linn, Pärnumaa EST0Professors emeritus, Faculty of Social Sciences0associate Professors emeritus, Faculty of Social Sciences0Faculty of MedicineDean's Office, Faculty of MedicineRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Biomedicine and Translational MedicineBiomeedikum, Ravila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of PharmacyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of DentistryL. Puusepa 1a 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Clinical MedicineL. Puusepa 8 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Family Medicine and Public HealthRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Sport Sciences and PhysiotherapyUjula 4 51008 Tartu linn, Tartu linn, Tartumaa ESTprofessors emeritus, Faculty of Medicine0associate Professors emeritus, Faculty of Medicine0Faculty of Science and TechnologyDean's Office, Faculty of Science and TechnologyVanemuise 46 - 208 51003 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Computer ScienceNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa ESTInstitute of GenomicsRiia 23b/2 51010 Tartu linn, Tartu linn, Tartumaa ESTEstonian Marine Institute0Institute of PhysicsInstitute of ChemistryRavila 14a 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Mathematics and StatisticsNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of Molecular and Cell BiologyRiia 23, 23b - 134 51010 Tartu linn, Tartu linn, Tartumaa ESTTartu ObservatoryObservatooriumi 1 61602 Tõravere alevik, Nõo vald, Tartumaa EST0Institute of TechnologyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Ecology and Earth SciencesJ. Liivi tn 2 50409 Tartu linn, Tartu linn, Tartumaa ESTprofessors emeritus, Faculty of Science and Technology0associate Professors emeritus, Faculty of Science and Technology0Area of Academic SecretaryHuman Resources OfficeUppsala 6, Lossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Area of Head of FinanceFinance Office0Area of Director of AdministrationInformation Technology Office0Administrative OfficeÜlikooli 17 (III korrus) 51005 Tartu linn, Tartu linn, Tartumaa EST0Estates Office0Marketing and Communication OfficeÜlikooli 18, ruumid 102, 104, 209, 210 50090 Tartu linn, Tartu linn, Tartumaa EST0Area of RectorRector's Strategy OfficeInternal Audit OfficeArea of Vice Rector for Academic AffairsOffice of Academic AffairsUniversity of Tartu Youth AcademyUppsala 10 51003 Tartu linn, Tartu linn, Tartumaa ESTStudent Union OfficeÜlikooli 18b 51005 Tartu linn, Tartu linn, Tartumaa EST0Centre for Learning and TeachingArea of Vice Rector for ResearchUniversity of Tartu LibraryW. Struve 1 50091 Tartu linn, Tartu linn, Tartumaa ESTGrant OfficeArea of Vice Rector for DevelopmentCentre for Entrepreneurship and InnovationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0University of Tartu Natural History Museum and Botanical GardenVanemuise 46 51003 Tartu linn, Tartu linn, Tartumaa EST0International Cooperation and Protocol Office0University of Tartu MuseumLossi 25 51003 Tartu linn, Tartu linn, Tartumaa EST0
Antti Matvere defends his PhD thesis
Antti Matvere will defend his doctoral thesis in cell biology entitled "Studies on aryl hydrocarbon receptor in murine granulosa cells and human embryonic stem cells" on March 30 at 12:15.
The supervisors of the thesis are Professor Toivo Maimets and Professor Arnold Kristjuhan, the Institute of Molecular and Cell Biology.
The opponent is Professor Xavier Coumoul, University Paris Descartes, France.
The location of the event is Riia 23b/2 auditorium 105 and the event can also be followed online.
Meeting ID: 935 7809 4823
Passcode: 891779
The thesis is available here: DSpace
Thesis summary:
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. It was initially discovered as a mediator of toxic effects of various environmental pollutants, secreted into the environment as organic waste. These include a wide range of polycyclic and halogenated aryl hydrocarbons, including the highest affinity AHR ligand TCDD. However, research over the past few decades has revealed that AHR has a broad range of functions other than being a sensor to toxic substances. Evidence for this has derived from studies using Ahr knockout animal models as well as the gained knowledge about the vast number of endogenous ligands for AHR. The role of AHR in regulating cellular homeostasis has been shown in various organs and tissues, most prominently in the immune system, liver, lung, fat tissue, brain and cancer. Additionally, AHR has been discovered to be important in reproductive system and in stem cells. Clinical sampling of AHR expression as well as basic research studying the role of AHR has paved way to the prospect of using this protein as a therapeutic target. Today’s research is widely focused on of its potential to serve as a marker in various diseases, but also as being a cellular target in modulation of treatment outcomes. However, the knowledge about the exact functions of this protein is far from complete. In addition, studies have implied AHR to have cell- and tissue-specific functions. The complex nature of this protein has urged to study its expression and functions in different cells. The current thesis focused on characterizing the expression of Ahr gene in murine granulosa cells and human embryonic stem cells. A particular focus was placed on elucidating the regulatory mechanisms controlling Ahr expression. In addition, this thesis aimed to expand the knowledge on the roles of AHR in cellular homeostasis by identification of novel AHR target genes.
Photo: Indrek Teino