The main focus of our research group is the development of disease models and new therapies based on the results of patient tissue analysis. Particular attention is paid to regeneration disorders (chr

Survival and life of cells depend on accurate and faithful inheritance and expression of their genetic information in the course of DNA replication and gene transcription. These processes are highly regulated in multiple levels, including by the regulation of DNA accessibility in chromatin. The general aim of our research is to clarify the role of chromatin in regulation of these fundamental processes in eukaryotic cells.

Most bacteria live in biofilm, at least for some stage of life. We study the attachment of the cosmopolitan bacterium Pseudomonas putida, to the surface and the regulation of biofilm.

We have been studying the efficacy and mode of action of antimicrobial materials and coatings in cooperation with material scientists since 2015.

Our current research focus is the role of DNA copy-number changes in female reproductive ageing and infertility, chromosomal instability in human, and bovine as a model, early embryos. In addition development and implementation of new methods for transcriptomics, genome editing and epigenetic profiling of small number of cells to enable functional studies from well-defined cell populations including embryonic- and stem-cells. 

One of the key processes in the animal development is morphogenesis, the process by which the shape of tissues / organs is formed.

We are interested on the fundamental aspects of protein biosynthesis. In this respect we use E. coli as a model system. We study functional topography of the bacterial ribosome. In addition, we analyz

We are interested in understanding the protein synthesis machinery in eukaryotes. The genetic information encoded in messenger RNA is translated into proteins by large ribonucleoprotein complex called

Bioinformatics research group

Our research is focused on the response of microbial communities to anthropogenic and natural stressors in different environments.

Bacteria evolve rapidly under stress conditions where their growth is inhibited due to unfavorable growth conditions.

The research focuses on the stringent response of bacteria. Stringent response is a universal mechanism in bacteria to survive stress. It is governed by the alarmone (p)ppGpp that is produced by RSH (RelA-SpoT homologue) enzymes. When the level of (p)ppGpp in cells increases, the growth of bacteria decreases, which helps them survive stressful conditions.

We are using efficient expression systems to produce heterologous proteins from pro- and eukaryotic organisms in Escherichia coli. We have expressed glucoside hydrolases (e.g. levansucrases, α-glucosi

Nature contains chemical compounds that are degraded by the catabolic activities of microorganisms to generate the energy and to support the world-wide life cycle.

. Mitochondrion is best known as the major site of ATP synthesis, but it is also involved in many other metabolic processes, e.g. synthesizing a number of metabolites that are important for various cellular processes.

Mitochondria are organelles that have their own genomic DNA. We are interested in the mechanisms by which the mitochondrial genome is propagated during the cell cycle.

Structural polysaccharides – cellulose and chitin – are the most abundant polysaccharides on the Earth and represent a huge reservoir of renewable carbon.