The Institute of Molecular and Cell Biology of the University of Tartu teaches the offspring of young researchers at all levels. Our researchers are at the top level in world-class science.
ResearchTissue regeneration research group, led by Assoc. Prof. Viljar Jaks, published an article in journal Cellular and Molecular Life Sciences. Olfactomedin-4 (OLFM4) regulates cell adhesion, proliferation, gastrointestinal inflammation, innate immunity and cancer metastasis. In the study they investigated its role in skin regeneration. In vivo experiments utilizing mouse splinted full-thickness cutaneous wound healing model showed that application of recombinant OLFM4 protein can significantly improve wound healing efficacy.
Cell Mol Life Sci: Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades