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Research News: Mariliis Klaas, a Research Fellow in Cell Biology, et al. published an article on the role of glycoprotein OLFM4 in skin regeneration
Tissue regeneration research group, led by Assoc. Prof. Viljar Jaks, published an article in journal Cellular and Molecular Life Sciences. Olfactomedin-4 (OLFM4) regulates cell adhesion, proliferation, gastrointestinal inflammation, innate immunity and cancer metastasis. In the study they investigated its role in skin regeneration. In vivo experiments utilizing mouse splinted full-thickness cutaneous wound healing model showed that application of recombinant OLFM4 protein can significantly improve wound healing efficacy.Cell Mol Life Sci: Olfactomedin-4 improves cutaneous wound healing by promoting skin cell proliferation and migration through POU5F1/OCT4 and ESR1 signalling cascades