Developmental biology research group
One of the key processes in the animal development is morphogenesis, the process by which the shape of tissues / organs is formed. During development, many morphogenetic events involve rearrangement of simple 2D cell layers into complex 3D tissues. In the last several decades experiments on different model organisms has revealed that certain group of highly conserved signaling molecules are repeatedly utilized in various stages and processes of development. Despite the increasing knowledge of the molecular basis of morphogenesis, how the activity of these signaling pathways is translated into changes in cell behavior and how cell shape changes affect developmental signaling, remain poorly understood. Since morphogenesis involves coordinated dynamic cellular processes (e.g. cytoskeleton remodeling, cell migration, cell shape changes, cell proliferation), tracking morphogenetic events in a spatial-temporal manner is crucial for understanding the mechanisms of development.
Our team uses the developing wing of the Drosophila melanogaster (fruit fly) as a model to elucidate, how the dynamics of tissue morphogenesis and communication between cells are regulated. We expect that our projects will provide novel insights into how dynamics cell-cell communication leads to 3D morphogenesis, and anticipate that our findings will have implications for understanding human pathogenesis of developmental disorders.
Image used in header: The developing wing of the Drosophila melanogaster (author: Osamu Shimmi)
Toddie-Moore, D.J., Montanari, M.P., Vi Tran, N., Brik, E.M., Antson, H., Salazar-Ciudad, I. and Shimmi, O. (2021). Mechano-chemical feedback mediated competition for BMP signalling leads to pattern formation. Dev. Biol. 431, 48-51
Montanari, M.P., Vi Tran, N. and Shimmi, O. (2021). Regulation of spatial distribution of BMP ligands for pattern formation. Dev. Dyn
Gui, J., Huang, Y., Montanari, M., Toddie-Moore, D., Kikushima, K., Nix, S., Ishimoto, Y. and Shimmi, O. (2019). Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 116, 4352-4361
Gui, J., Huang, Y. and Shimmi, O. (2016). Scribbled Optimizes BMP Signaling through its Receptor Internalization to the Rab5 Endosome and Promote Robust Epithelial Morphogenesis. PLoS Genetics 12(11), e1006424
Tauscher, P., Gui, J. and Shimmi, O. (2016). Adaptive protein divergence of BMP ligands takes place under developmental and evolutionary constraints. Development 143, 3742-3750
- 2022. a. juunikuu Eesti Looduse numbris jätkasid TÜMRI teadlased Osamu Shimmi, Tambet Tõnissoo ja Sulev Kuuse eelmises kuus ilmunud artiklit, kus anti ülevaade biokuvamisest. Seekord kirjutasid teadlased, kuidas saab jälgida molekule ja rakuorganelle ning mil moel võivad uued meetodid olla kasulikud meditsiinis.
- 2022. a. maikuu Eesti Looduse numbris avaldasid TÜMRI teadlased Osamu Shimmi, Tambet Tõnissoo ja Sulev Kuuse artikli, kus teemaks on põnev tehnoloogia: biokuvamine.
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TÜMRI arengubioloogia õppetooli juhataja, kaasprofessor Tambet Tõnissoo, kirjutab ajakirjas Eesti Loodus teemal: „Kuhu küll kõik karvad jäid?“ Eesti Loodus, 03.2022
- Ajakirja Eesti Loodus 2021. a. detsembrinumbris ilmus TÜMRI arengubioloogia õppetooli juhataja ja arengubioloogia kaasprofessori Tambet Tõnissoo sulest põnev artikkel, milles ta kommenteerib kalifornia kondorite partenogeneesi.
- Ajakirja Eesti Loodus 2021.a. märtsinumbris vestleb Tartu Ülikooli arengubioloogia professori Osamu Shimmiga arengubioloogia kaasprofessor Tambet Tõnissoo.
