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Faculty of Arts and HumanitiesDean's Office, Faculty of Arts and HumanitiesJakobi 2, r 116-121 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of History and ArchaeologyJakobi 2 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Estonian and General LinguisticsJakobi 2, IV korrus 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Philosophy and SemioticsJakobi 2, III korrus, ruumid 302-337 51005 Tartu linn, Tartu linn, Tartumaa EST0Institute of Cultural ResearchÜlikooli 16 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of Foreign Languages and CulturesLossi 3 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Theology and Religious StudiesÜlikooli 18 50090 Tartu linn, Tartu linn, Tartumaa EST0Viljandi Culture AcademyPosti 1 71004 Viljandi linn, Viljandimaa EST0Professors emeriti, Faculty of Arts and Humanities0Associate Professors emeriti, Faculty of Arts and Humanities0Faculty of Social SciencesDean's Office, Faculty of Social SciencesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Institute of EducationJakobi 5 51005 Tartu linn, Tartu linn, Tartumaa EST0Johan Skytte Institute of Political StudiesLossi 36, ruum 301 51003 Tartu linn, Tartu linn, Tartumaa EST0School of Economics and Business AdministrationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of PsychologyNäituse 2 50409 Tartu linn, Tartu linn, Tartumaa EST0School of LawNäituse 20 - 324 50409 Tartu linn, Tartu linn, Tartumaa EST0Institute of Social StudiesLossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Narva CollegeRaekoja plats 2 20307 Narva linn, Ida-Virumaa EST0Pärnu CollegeRingi 35 80012 Pärnu linn, Pärnu linn, Pärnumaa EST0Professors emeriti, Faculty of Social Sciences0Associate Professors emeriti, Faculty of Social Sciences0Faculty of MedicineDean's Office, Faculty of MedicineRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Biomedicine and Translational MedicineBiomeedikum, Ravila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of PharmacyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of DentistryL. Puusepa 1a 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Clinical MedicineL. Puusepa 8 50406 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Family Medicine and Public HealthRavila 19 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Sport Sciences and PhysiotherapyUjula 4 51008 Tartu linn, Tartu linn, Tartumaa ESTProfessors emeriti, Faculty of Medicine0Associate Professors emeriti, Faculty of Medicine0Faculty of Science and TechnologyDean's Office, Faculty of Science and TechnologyVanemuise 46 - 208 51003 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Computer ScienceNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa ESTInstitute of GenomicsRiia 23b/2 51010 Tartu linn, Tartu linn, Tartumaa ESTEstonian Marine Institute0Institute of PhysicsInstitute of ChemistryRavila 14a 50411 Tartu linn, Tartu linn, Tartumaa EST0Institute of Mathematics and StatisticsNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0Institute of Molecular and Cell BiologyRiia 23, 23b - 134 51010 Tartu linn, Tartu linn, Tartumaa ESTTartu ObservatoryObservatooriumi 1 61602 Tõravere alevik, Nõo vald, Tartumaa EST0Institute of TechnologyNooruse 1 50411 Tartu linn, Tartu linn, Tartumaa ESTInstitute of Ecology and Earth SciencesJ. Liivi tn 2 50409 Tartu linn, Tartu linn, Tartumaa ESTProfessors emeriti, Faculty of Science and Technology0Associate Professors emeriti, Faculty of Science and Technology0Institute of BioengineeringArea of Academic SecretaryHuman Resources OfficeUppsala 6, Lossi 36 51003 Tartu linn, Tartu linn, Tartumaa EST0Area of Head of FinanceFinance Office0Area of Director of AdministrationInformation Technology Office0Administrative OfficeÜlikooli 17 (III korrus) 51005 Tartu linn, Tartu linn, Tartumaa EST0Estates Office0Marketing and Communication OfficeÜlikooli 18, ruumid 102, 104, 209, 210 50090 Tartu linn, Tartu linn, Tartumaa EST0Area of Vice Rector for DevelopmentCentre for Entrepreneurship and InnovationNarva mnt 18 51009 Tartu linn, Tartu linn, Tartumaa EST0University of Tartu Natural History Museum and Botanical GardenVanemuise 46 51003 Tartu linn, Tartu linn, Tartumaa EST0International Cooperation and Protocol Office0University of Tartu MuseumLossi 25 51003 Tartu linn, Tartu linn, Tartumaa EST0Area of RectorRector's Strategy OfficeInternal Audit OfficeArea of Vice Rector for Academic AffairsOffice of Academic AffairsUniversity of Tartu Youth AcademyUppsala 10 51003 Tartu linn, Tartu linn, Tartumaa EST0Student Union OfficeÜlikooli 18b 51005 Tartu linn, Tartu linn, Tartumaa EST0Centre for Learning and TeachingArea of Vice Rector for ResearchUniversity of Tartu LibraryW. Struve 1 50091 Tartu linn, Tartu linn, Tartumaa EST0Grant Office
Biotechnology research group
15.11.2024
Activation of the bovine early embryonic genome
Use of inert microfluidics to separate extracellular microvesicles from blood
Elucidation of the mechanisms of chromosomal instability in early embryogenesis
Functional genomics - transgenic reporter methods to assess the effects of diseases and selection-related genetic variants on gene expression.
Production and growth of human-induced pluripotent cells for functional assays.
Early diagnosis of colorectal cancer.
Development of new genomics methods
Use of inert microfluidics to separate extracellular microvesicles from blood
Elucidation of the mechanisms of chromosomal instability in early embryogenesis
Functional genomics - transgenic reporter methods to assess the effects of diseases and selection-related genetic variants on gene expression.
Production and growth of human-induced pluripotent cells for functional assays.
Early diagnosis of colorectal cancer.
Development of new genomics methods
Changes in DNA copy number during reproductive aging in women
functional genomics
functional transcriptomics
study of genome editing and epigenetic changes
functional genomics
functional transcriptomics
study of genome editing and epigenetic changes
Our current research focus is the role of DNA copy-number changes in female reproductive ageing and infertility, chromosomal instability in human, and bovine as a model, early embryos. In addition development and implementation of new methods for transcriptomics, genome editing and epigenetic profiling of small number of cells to enable functional studies from well-defined cell populations including embryonic- and stem-cells.
We are collaborating with the Center of Genomics, Evolution and Medicine (cGEM) to implement functional genomics assays to study how DNA polymorphisms contribute to phenotypic variation. As a model system we have set up a workflow to create induced pluripotent stem cells (iPSCs). This will allow to create person specific cell-lines that self renew, are pluripotent and can thus be used to model different tissues or diseases. In parallel, we are developing high throughput assays such as massively parallel reporter assay (MPRA) that allows us to assess the gene regulatory activity of thousands of genomic regions in parallel.
Image used in header: mouse embryos (author: Baris Yasar, PhD student)
- Yaşar, B., Boskovic, N., Ivask, M., Weltner, J., Jouhilahti, E., Viil, P., Skoog, T., Jaakma, Ü., Kere, J., Bürglin, T., Katayama, S., Org, T., Kurg, A. (2024). Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos. BMC Genomics 25, 1048. DOI: https://doi.org/10.1186/s12864-024-10969-w
- Essers, Rick & Lebedev, Igor & Kurg, Ants & Fonova, Elizaveta & Stevens, Servi & Koeck, Rebekka & Rango, Ulrike & Brandts, Lloyd & Deligiannis, Spyridon-Panagiotis & Nikitina, Tatiana & Sazhenova, E. & Tolmacheva, Ekaterina & Kashevarova, Anna & Fedotov, Dmitry & Demeneva, Viktoria & Zhigalina, Daria & Drozdov, Gleb & Al-Nasiry, Salwan & Macville, Merryn & Zamani Esteki, Masoud. (2023). Prevalence of chromosomal alterations in first-trimester spontaneous pregnancy loss. Nature Medicine. 29. DOI:10.1038/s41591-023-02645-5
- Krigul KL, Aasmets O, Lüll K, Org T, Org E. Using fecal immunochemical tubes for the analysis of the gut microbiome has the potential to improve colorectal cancer screening. Sci Rep. 2021 Oct 1;11(1):19603. doi: 10.1038/s41598-021-99046-w
- Rooda I, Hensen K, Kaselt B, Kasvandik S, Pook M, Kurg A, Salumets A, Velthut-Meikas A. Target prediction and validation of microRNAs expressed from FSHR and aromatase genes in human ovarian granulosa cells. Sci Rep. 2020 Feb 10; 10(1):2300. doi: 10.1038/s41598-020-59186-x
- Hensen K, Pook M, Sikut A, Org T, Maimets T, Salumets A, Kurg A. Utilising FGF2, IGF2 and FSH in serum-free protocol for long-term in vitro cultivation of primary human granulosa cells. Mol Cell Endocrinol. 2020 Apr 12:110816. doi: 10.1016/j.mce.2020.110816
- Zamani Esteki M, Viltrop T, Tšuiko O, Tiirats A, Koel M, Nõukas M, Žilina O, Teearu K, Marjonen H, Kahila H, Meekels J, Söderström-Anttila V, Suikkari AM, Tiitinen A, Mägi R, Kõks S, Kaminen-Ahola N, Kurg A, Voet T, Vermeesch JR, Salumets A. In vitro fertilization does not increase the incidence of de novo copy number alterations in fetal and placental lineages. Nat Med. 2019 Nov 4. doi: 10.1038/s41591-019-0620-2
- Org T, Hensen K, Kreevan R, Mark E, Sarv O, Andreson R, Jaakma Ü, Salumets A, Kurg A. Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP. PLoS One. 2019 Nov 25;14(11):e0225801. doi: 10.1371/journal.pone.0225801
Tartu Ülikooli molekulaar- ja rakubioloogia instituut: „Ettevõtetega koostöös otsitakse võimalusi veremürgituse kiiremaks diagnoosimiseks“
Contact (research group leader):
Ants Kurg
Institute of Molecular and Cell Biology
Chair of Biotechnology
Head of Chair, Professor of Molecular Biotechnology
Riia 23-201
+372 737 5018